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Cigarette smoking is the leading cause of preventable death in the United States.1

Cigarette smoking causes more than 480,000 deaths each year in the United States. This is nearly one in five deaths.1,2,3
Smoking causes more deaths each year than the following causes combined:4
- Human immunodeficiency virus (HIV)
- Illegal drug use
- Alcohol use
- Motor vehicle injuries
- Firearm-related incidents
More than 10 times as many U.S. citizens have died prematurely from cigarette smoking than have died in all the wars fought by the United States.1
Smoking causes about 90% (or 9 out of 10) of all lung cancer deaths.1,2 More women die from lung cancer each year than from breast cancer.5
Smoking causes about 80% (or 8 out of 10) of all deaths from chronic obstructive pulmonary disease (COPD).1
Cigarette smoking increases risk for death from all causes in men and women.1
The risk of dying from cigarette smoking has increased over the last 50 years in the U.S.1

Smokers are more likely than nonsmokers to develop heart disease, stroke, and lung cancer.1

Estimates show smoking increases the risk:
- For coronary heart disease by 2 to 4 times1,6
- For stroke by 2 to 4 times1
- Of men developing lung cancer by 25 times1
- Of women developing lung cancer by 25.7 times1
Smoking causes diminished overall health, increased absenteeism from work, and increased health care utilization and cost.1

Smokers are at greater risk for diseases that affect the heart and blood vessels (cardiovascular disease).1,2

Smoking causes stroke and coronary heart disease, which are among the leading causes of death in the United States.1,3
Even people who smoke fewer than five cigarettes a day can have early signs of cardiovascular disease.1
Smoking damages blood vessels and can make them thicken and grow narrower. This makes your heart beat faster and your blood pressure go up. Clots can also form.1,2
A stroke occurs when:
- A clot blocks the blood flow to part of your brain;
- A blood vessel in or around your brain bursts.1,2
Blockages caused by smoking can also reduce blood flow to your legs and skin.1,2

Smoking can cause lung disease by damaging your airways and the small air sacs (alveoli) found in your lungs.1,2

Lung diseases caused by smoking include COPD, which includes emphysema and chronic bronchitis.1,2
Cigarette smoking causes most cases of lung cancer.1,2
If you have asthma, tobacco smoke can trigger an attack or make an attack worse.1,2
Smokers are 12 to 13 times more likely to die from COPD than nonsmokers.1

Smoking can cause cancer almost anywhere in your body:1,2

Smoking also increases the risk of dying from cancer and other diseases in cancer patients and survivors.1

If nobody smoked, one of every three cancer deaths in the United States would not happen.